University of Mangalore obtains patent for invention of anticancer compound

The invention is entitled, A process for the extraction and purification of tetrandrine

The University of Mangalore obtained its first patent for an invention from its two plant researchers KR Chandrashekar and Bhagya Nekrakalaya concerning an anti-cancer compound.

The invention is entitled A Process for the Extraction and Purification of Tetrandrine.

Tetradrine is an anticancer compound.

The invention describes a process for the extraction and purification of tetrandrine from a methanolic extract of Cyclea peltata, which is commonly known in Kannada as Haade balli, collected from the natural forests of Dakshina Kannada and Kasaragod district in Kerala.

The Patent Office granted the patent (No. 369124) to the researchers on June 11, 2021. It is valid for 20 years from May 8, 2017 since they filed a patent application during their research at the University. from Mangalore. At present, the two researchers are working at Yenepoya reputed to be Mangaluru University.

Mr Chandrashekar, who retired as Chairman and Professor of Botany, Department of Applied Botany, University of Mangalore, said The Hindu this Cyclea peltata (Lam.) Hook. F. Thomas. (Menispermaceae) is an herb of ethnomedical significance used in the treatment of various health problems.

It is reported to have anti-toxin function in addition to playing a role in improving diabetic skin disorders, such as boils and anthrax, and in treating smallpox and upset stomach. Pharmacological studies have also proven the bioactive potential of Cyclea peltata with antioxidant, antidiabetic, anti-inflammatory, cytotoxic activities and protection against nephrotoxicity and oxidative damage.

He said that as an alkaloid, small organic molecules containing nitrogen usually in a ring, tetrandrine was previously isolated from Stephanie tetrandra, a widely cited ethnomedicinal plant in China that has shown anticancer, antimicrobial, anti-inflammatory, antidiabetic, antioxidant, immunosuppressive, cardiovascular and calcium channel blocking effects. Several studies have shown the effective in vitro and in vivo anticancer mechanism of tetrandrine against different cancers by acting on multiple pathways.

The two researchers working on tissue culture and plant bioprospecting in the Western Ghats found the presence of tetrandrine in Haade balli. They tested its anticancer potential using cancer cells. In addition, they developed a simple process for its plant extraction and purification into a single molecule from a complex mixture using a simple glass column chromatography technique.

“The recrystallized fractions gave tetrandrine with a purity of 98.63%. Further work on this molecule with regard to increasing its solubility in an aqueous medium and clinical trials could lead to the development of a potent anti-cancer drug from a local plant, ”the researchers said.

Ms. Nekrakalaya is a UGC Women Scientist Postdoctoral Fellow at Yenepoya Deemed to University, Mangaluru, and Mr. Chandrashekar is Advisor, Internal Quality Assurance Cell, and Professor of Botany at Yeneopoya Deemed to be University.

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